Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Through an enormous experimental effort 1, 2, 3, 4, the structures of around 100,000 unique proteins have been determined 5, but this represents a small fraction of the billions of known protein sequences 6, 7. Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function.
Nature volume 596, pages 583–589 ( 2021) Cite this article Highly accurate protein structure prediction with AlphaFold
0 kommentar(er)
